To assist development of missile weapon system, virtual prototype validation technique is used for modeling and simulation of certain type missile system. The paper introduces the framework of certain type missile virtual prototype, and puts forward the validation method: virtual prototype model validation can be graded as a process stage by stage, from sub model, control model to control and guide system. The validation result indicates, which has been validated by this way, the model not only forecast the missile performance, but also analyzes the testing problem. All these give a foundation of missile simulation and evaluation.