To make EBS and MES system seamless integration and further enhance the enterprise’s production efficiency and the ability of rapid response market, we developed a system of manufacturing execution system (MES) platform interface based on ORACLE EBS. Analyze and design the MES based on the ORACLE EBS application platform interface development of information flow model. The article introduce system interfaces, which from EBS to MES, including code interface, work order information and process information interface design; as well as from MES to EBS interface, including the production task process feedback, resources usage, production task completion interface design, finally achieved the system EBS and MES seamless integration. The application results indicate that the integrated method can further improve current process and realize enterprise management and workshop management integration standard operation, and thereby more effectively reduce product cycle and improve labor productivity.