Wind tunnel measure and control system with sand and dust is designed to avoid invalidation of weapon in sand and dust. Introduce the system in hardware design and software design. Aiming at the difficulties in system design, discuss the methods for key difficulties such as sand and dust consistency control, serial port communication and alarming design, and apply it. In application, it works well with fast response, high control precision and low bit error ratio in serial communication. It can also satisfy high speed data acquisition demand.