Nowdays, with the higher requirement for high performance, high bandwidth and hush environment resistant computing platform, an advanced computing platform based on versatile protocol switch (VPX) bus is proposed. Introduce the development history of the VPX bus, indicate the critical issues need to be solved by the advanced computing platform based on VPX bus, the bus architecture, discuss the design in detail and carry out long-time test under different environment. The test result indicates that the platform has high performance, high bandwidth, excellent stability, strong anti-interference capability and easy maintenance; therefore, it is an industrial computing platform appropriate for severe environment.