For fixing limit anti-surge control method defects, using the new variable limit anti-surge system, the multiple anti-surge method is designed. The principle of the control system and control method is introduced. Aiming to surge, set different control lines. According to different control lines, creates different control responses. The Combine close-loop PI control with open-loop control and the multiple anti-surge methods are designed, and experimental verification in refrigeration system by compressing air. The results showed that the system is reliable, and the parameters in the range of allowable error. The set value can be reached accurately, and in a stable state for a long time. The surge is controlled effectively.