The new generation object-oriented simulation software Simio is used to model, simulate and analyze the complex queue system, since it is difficult to solve these related problems with traditional numerical methods. A simulation model of queue system is built, and then statistics and analysis of this mode are carried out. In addition, two improved solutions to the original system are modeled, simulated and vivificated. The result shows, it is convenient to model a queue system and its related problems in various fields, based on Simio.