In order to solve the crowded collision problem of large-scale unmanned aerial vehicle (UAV) group flight, a flight control method of UAV group flight based on speed information guidance is proposed. Accord to that method, the flight route of the UAV clust is divided into two stages, namely an initial cluster stage and a flight route stage. An individual expected speed of the unmanned aerial vehicle is designed according to a cluster rule constrained by the relative position and the speed of the unmanned aerial vehicle and a neighbor of the unmanned aerial vehicle to realize orderly cluster of the unmanned aerial vehicle; The virtual leader is introduced to track the preset route and embedded into each UAV, and the consistency algorithm is used to ensure that the information of each virtual leader is consistent. At the same time, the UAV cluster tracks the speed of its own virtual leader, and adjusts the expected speed of the UAV with the help of the established route tracking error model, and analyzes the process by using the order parameter, the cluster tracking route error and the dispersion difference. The simulation results show that the UAV can effectively cluster and achieve highly accurate route fitting, and successfully complete the cluster route flight.