In order to enhance the penetration ability of the damage element formed by the combined liner in water, a cone-spherical shaped charge liner was designed. By changing the material of cone-sphere shaped charge liner, the simulation scheme was determined to carry out numerical simulation. The results of different material matching of cone-sphere combined liner show that the penetration ability of the warhead is the strongest when Al-W is used; the penetration aperture of the warhead is the largest when Al-Al is used; the penetration depth of the warhead is the largest when Al-W is used; the comprehensive performance of its penetration target is more significant when Al-Cu is used.