Aiming at the problem that the digitalization degree of initiating explosive device production line is generally not high, the equipment-model-monitoring synchronization method of virtual and real workshop and physical workshop is proposed. Taking a domestic initiating explosive device assembly workshop as the application object, the four-layer digital twin architecture of data acquisition, data management, digital modeling and function integration application is designed, and the key technologies of real-time data acquisition, digital twin model construction and equipment-model-monitoring synchronization between virtual and physical workshops are described in detail. Based on Unity3D software, the digital twin system is developed and implemented to verify the correctness and effectiveness of the proposed scheme. The application results show that the technology realizes the construction of digital twin in assembly workshop, and provides a technical solution for the realization of digital twin in the production process of initiating device workshop, which has a certain reference value.