The influence of NiCr3O5 damping coating on the vibration characteristics of thin-walled components of ejector pipes was studied in order to solve the problem that the ejector pipes are prone to fatigue cracks due to severe vibration. NiCr3O5 damping coating was sprayed on the weld seam of the wind tunnel ejector pipe by using a self-developed portable high velocity oxygen fuel (HVOF) spraying device. The natural characteristics, vibration response and damping of the ejector pipe before and after coating were experimentally studied and numerically simulated, and the results were compared with the experimental results. The results show that the NiCr3O5 coating can improve the damping performance of the thin-walled structure of the wind tunnel ejector and reduce the fatigue damage caused by the airflow vibration.