Aiming at the trend that the ammunition storage, use and management of large amphibious ships are becoming more and more complex, the loading requirements of various types of ammunition for large amphibious ships are analyzed. According to the operation and use characteristics of all kinds of equipment and ammunition, the ship-to-bomb suitability system of large amphibious warship is constructed from four aspects of storage, transshipment, command management and special situation safety, and the corresponding evaluation criteria and methods are put forward. The results show that this method can provide auxiliary support and reference for the design and optimization of the overall design scheme of large amphibious ships and the design and optimization of ammunition related systems.