In order to solve the problems of slow resource information processing efficiency, information error caused by local information processing asymmetry and large maintenance investment in traditional human resource management system, a human resource information management system based on cloud computing technology is proposed. Using B/S interactive interface as the framework layout scheme, the software algorithm is designed from four parts: the cloud computing parameter processing of human resource information, the design of cloud computing storage model of human resource information management, the construction of decision tree of human resource information cloud computing management and the encrypted storage of hospital human resource information based on cloud computing. By analyzing the data obtained from the comparative experiments with three different systems, it is shown that the system can effectively improve the management efficiency, ensure the security of information storage, eliminate the error of resource calculation, and improve the overall total energy performance of the system.