Aiming at the problems existing in the traditional hydropower station management system, an intelligent safety management platform for hydropower station based on whole process data monitoring is proposed. Using mobile Internet, cloud computing and big data technology for research and analysis, the system development includes four functions: security knowledge base, security supervision, assistant decision support and system management; With the development of data docking interface with other systems of hydropower station, the whole process of multi-system integration linkage is realized, the safety monitoring system of hydropower station is built, and the whole process of safety closed-loop management is formed, which achieves the effects of eliminating safety supervision loopholes and blind areas, saving manpower and improving work efficiency. The results show that the platform has great promotion value for the intelligent safety management of hydropower station.