In order to effectively improve the accuracy of load decentralized dispatching, a load decentralized dispatching method of regional power system under new energy access is proposed. Collect the operation state data of the power system when the new energy is connected, and denoise the collected data to improve the quality of the system operation state data; according to the results of data denoising, the objective function and constraint conditions of decentralized dispatching of regional power system suitable for new energy access are established, and the construction of load decentralized dispatching model of regional power system is completed. The improved genetic algorithm is used to solve the model, and the optimal solution of decentralized dispatching of regional power system is determined according to the solution results, so as to realize the decentralized dispatching of regional power system under the access of new energy. The experimental results show that when this method is used to carry out decentralized dispatching of regional power system, the dispatching effect is good and the performance is high.