In order to solve the problem of location decision of war storage depots in different strategic directions, a location decision model of war storage depots based on GA-BP neural network is proposed. By analyzing the influencing factors of the location of war storage depots, the decision index system of the location of war storage depots is constructed; Based on BP neural network, a location decision model is established, and genetic algorithm (GA) is used to optimize the weights and thresholds of back propagation (BP) neural network, and an example is given to prove that genetic algorithm optimization of BP neural network can improve the efficiency and accuracy of location decision. The results show that the research can provide ideas and methods for the site selection of war storage depots.