In order to improve the damage capability of anti-satellite weapons, the design scheme of focusing tungsten ball warhead was proposed. Combined with theoretical analysis and numerical simulation method, the action mechanism of single-layer, double-layer and three-layer tungsten sphere directed killing warhead was analyzed, and the simulation results were analyzed by Matlab software, and the distribution shape, density and distribution space of fragment group at 100 m were calculated. By calculating the damage probability of tungsten sphere, the comprehensive analysis showed that the damage effect of double-layer arrangement directional warhead was the best. The results show that the scheme has a certain guiding significance for the design of space weapon warhead.