The information management system of financial budget in public hospitals has a high degree of operation failure, if the data type can not be accurately divided, it will lead to the operation failure of the system and affect the effect of information management of financial budget. Therefore, proposes the design of public hospital financial budget information management system based on principal component analysis (PCA). Design the overall framework of the public hospital financial budget information management system, analyze the performance of each module of the financial budget information management system, analyze the financial data through the PCA, complete the system database design, and design the software program implementation process combined with the specific functions of the hardware module; Integrate the designed hardware and software to complete the design of public hospital financial budget information management system. The experimental results show that the budget management system designed by the proposed method works well in the budget information management.