In order to improve the quality of cast thermosetting polymer-bonded explosive (PBX), the factors affecting the charge quality of cast PBX explosive with high solid content were analyzed. According to the relevant theory, the charging process parameters are designed by using the methods of vibration, vacuumizing and charging by stages, and the influence of different charging methods on the discharge of charge bubbles is analyzed through experiments. The results show that the vacuum-vibration-grading charge can effectively remove the bubbles in the cast PBX charge and increase the charge density to 98.5% TMD.