In order to solve the problem of personnel injury caused by combustion and explosion in the processing of energetic materials due to high processing temperature or improper operation, a set of control system for automatic processing equipment of energetic materials based on Beckhoff PLC is designed. The design process and function of the control system are described by introducing the mechanical structure, electrical hardware composition and software implementation of the equipment. The application results show that the system can realize automatic operation stably and efficiently, and has the functions of remote real-time monitoring and operation, which can effectively reduce the probability of accidents.