In order to solve the problem of choosing the right position to deploy the mobile shore-guided missile assault group to the sea, a position deployment optimization model of the shore-guided missile assault group is established. Taking maximizing the damage probability as the objective function and the fire coverage area of shore-to-ship missile as the constraint condition, the optimization scheme of position deployment is obtained by using genetic algorithm. The simulation results show that the method can save the range of the shore-to-ship missile, enhance the suddenness of the attack, and improve the hit probability. The firing direction of the shore-to-ship missile is given, which provides a reference for the commander’s decision-making.