In order to quickly estimate the delay of the specified network, the subnets of wired and wireless networks are modeled based on queuing theory, and the queuing network model of complex networks is constructed. In order to estimate the end-to-end delay quickly in complex networks, the opnet simulation tool is used to model and simulate the typical complex wired, wireless and wired plus wireless networks, and the relative errors are 16%, 9.9% and 13. 78% respectively by comparing the simulation results with the queuing network estimation results. The results show that the model can be used to analyze the network performance, simulate the complex communication network environment and optimize the network.