Aiming at the problem of azimuth Doppler ambiguity caused by spatial non-uniform sampling, an improved reconstruction filter bank based MIMO-ISAR high resolution imaging method for maneuvering targets is proposed. For the high maneuvering target model, the MIMO-ISAR echo model of multi-carrier LFM signal is constructed, and the target motion parameters are estimated by RWT (radon-Wigner transform) parameters, and then the filter bank is constructed according to the effective sampling rate of azimuth. The effectiveness of the algorithm is verified by experiments. The results show that the method can effectively solve the problem of azimuth Doppler ambiguity of maneuvering target.