In order to solve the problems of low efficiency of process data collaboration, insufficient accumulation and application of process knowledge, large amount of repetitive work and long cycle of process preparation, a rapid process design technology for aerospace cable components driven by model and knowledge was proposed. The key technologies of MBD-based cable structured design information extraction, the construction of cable structured process design knowledge base, and the intelligent generation of knowledge-based cable processing technology are analyzed. The software system based on B/S architecture is constructed and the application verification of model engineering is realized. The results show that the system can realize the rapid design of cable process, greatly improve the efficiency of cable assembly processing process design, and enhance the standardization of documents and the level of knowledge and intelligence of process design process.