In order to improve the quality of DNAN-based melt-cast explosive, the melt-cast explosive with the mass ratio of DNAN/RDX/AI/AP: 25/10/31/34 was taken as the research object. 2 different preparation processes were used to carry out comparative tests, and the internal and external defects, density and distribution uniformity of the melt-cast explosive were analyzed. The results showed that compared with the conventional technology, the production capacity of the improved technology was increased by 5 times, the process safety was improved, the defects of the block were greatly reduced, and the density distribution uniformity of the block was obviously improved.