In order to solve the problems of poor maneuverability, small stability margin and weak anti-disturbance ability of the aircraft with blended wing-body configuration, the active disturbance rejection technology is used to design the controller. According to the six-degree-of-freedom nonlinear model of the airliner with blended wing and body, the attitude control law of the airliner is designed based on the principle of active disturbance rejection controller (ADRC), and the parameters of ADRC are analyzed. The improved particle swarm optimization (PSO) algorithm is used to tune the parameters, and the mathematical model of the influence of the change of the center of gravity on the state of the passenger aircraft is established, and the attitude of the passenger aircraft is simulated under the condition that the center of gravity changes gradually; Turbulent wind disturbance was added in the vertical direction of the passenger plane, and the change of its overload was observed, and the ride comfort of the passenger plane was evaluated. The simulation results show that the ADRC can effectively control the attitude change of the aircraft. At the same time, when facing the change of the center of gravity and the disturbance of turbulent wind, the ADRC can stably control the aircraft. Therefore, the blended wing-body aircraft has strong robustness to the change of gravity center and the disturbance of turbulent wind, which ensures the safe flight of the aircraft and the comfort of passengers.