Aiming at the problem of high reliability and availability of key tooling resources in automatic production line, the life prediction of key tooling based on digital twin is analyzed. The definition and development of digital twin are described, the concept and prediction method of key tooling life are introduced, and how to use digital twin technology to realize the life prediction method of key tooling is analyzed and discussed. The analysis results show that it is necessary and feasible to apply the digital twin technology to the field of tool life prediction, which can effectively guarantee the efficient and high-quality production capacity of the intelligent production line.