For ensuring missile launch safety, research on design feasibility of missile storage and launch box and its dynamic characteristics during launch. Based on the multi-body dynamics theory, the launch system dynamics simulation analysis model is established, and the flow field analysis model of the storage and transportation launch box is established by using the Fluent software. The simulation analysis results show that the storage and transportation launch box has good compatibility with the missile and can meet the safety requirements of missile launch. The flight test results verify the validity of the design scheme and simulation analysis results.