In order to ensure that the clamping force of robot gripper is within the safe threshold of high-risk products and the output is stable, the typical example was taken as the gripping process of robot’s gripper commonly used in high-risk locations. This paper established the control system model of clamping force and proposed the simulation steps of continuous system and intelligent control. The fuzzy controller was designed and solved by Runge-Kutta iterative method. The results show that the clamping force is in the case of drift disturbance, it can quickly realize the stable and safe control of the clamping force.