Aiming at the problems of long assembly and test duration of multi-segment aircraft, the process is uninterrupted and irreversible, a fully redundant measurement system for mass and centroid is designed. Based on the structure and function of the main and standby systems, the 3-point support weighing method is used to measure the mass and centroid, a tare equivalent conversion method is proposed to simplify the measurement process, and the difference coefficient and nonlinear coefficient of the load cell are calibrated online. By analyzing the source of system error, using standard samples to test the system’ s mass and centroid. The experimental results show that the design measurement results have good consistency and can effectively improve the reliability of the measurement system.