In order to compare the aerodynamic characteristics of strategic large aircraft and early warning airplane with radar antenna, a 3D model of strategic large aircraft is designed by CATIA software. Based on computational fluid dynamics (CFD) technology, standard k-ε equation is applied to turbulence model of the air flow field, while fluid dynamics control theory adopts the 3D N-S equation. Then numerical simulation of the model is conducted in Fluent software, and the pressure coefficient diagram, velocity contour map and lift-resistance characteristics of the strategic large aircraft are obtained. The weight of the model and required thrust during horizontal flight are also calculated. The results show that the research can provide reference and technical support for the overall design of large aircraft.