Aiming at the problem of excessive launching disturbance of missile launching on the move, the dynamic simulation of missile launching from unmanned platform is carried out. By analyzing the main causes of the launching disturbance on the move, the rigid-flexible coupling dynamic simulation model of the weapon station was established, using the measured data of engine thrust and servo mechanism movement as simulation input, and calculate the disturbance value of the projectile with the dynamic model. The calculation results show that the improved fire control process can achieve the reliable launching of missile on the move, the launching threshold should be selected according to the anti-disturbance ability of the missile. The research can provide a reference for drawing up missile launching process and the selection of launching threshold.