In order to solve the problem of certain type hybrid image intensifier device in the process of production of high gain in high and low temperature, analyze the principle of temperature drift, and research on gain changing principle under room temperature, low temperature and high temperature, then use Minitab to analyze the correlation between the gain of the image intensifier and the temperature. Based on gain-temperature regression function fitting, we determined adjustment range of gain under room temperature. The results show that the risk of the gain drifting out of specified range was reduced, and the quality of the production were improved.