In order to find out the magnitude and distribution of noise excitation and the magnitude of skin response (vibration), the experiment of noise excitation and response measurement of ejector skin in 1.2 m wind tunnel and the optimization design based on Abaqus software mode were carried out. The structure of data acquisition system is given, measurement method is introduced, compared with the finite element analysis results of the existing structure (5 mm thick) and the optimized design scheme (8 mm thick). The reference data of structural optimization scheme are obtained. The results show that the design can effectively avoid the frequency of structure violent vibration caused by the change of air pulsation pressure: 400, 409, 460, 516, 561, 598 Hz, improve the rigidity and strength of the structure, improve the fatigue resistance of incremental ejector.