In order to solve the problem of parameter path separation, the typical telemetry frame structure and the key technology of data processing are analyzed. Based on the actual weapon test in shooting range, the definition of telemetry frame structure is briefly introduced. By analyzing the telemetry frame structures of three typical weapon systems, the key technologies in telemetry data processing are proposed based on the commonness and characteristics of telemetry frame structure. The application results show that the technology can optimize data processing links and improve data processing efficiency. It can provide reference for telemetry data processing of new weapon systems.