In order to enhance the protection ability of the armor target and improve the anti-penetration performance of the target board, the projectile is penetrating into the double-layer different material target panels for numerical simulation. The geometry and simulation model of the projectile penetrating the target plate were established. The ANSYS/LS-DYNA software was used to compare the anti-penetration ability of the three different material targets, and the anti-invasion of the double-layer target with or without spacing of different materials. The performance was numerically simulated, and the influence of different target arrangement order on the anti-penetration performance of the target combination was compared. The simulation results show that the anti-penetration ability of the two-layer target plate combination is related to the material and arrangement of the two-layer target plate. The double-layered space