In order to solve the problem of safe use performance and life requirements of the vehicle wheels, the dynamic radial fatigue life of the wheel was predicted. The finite element model under radial fatigue test conditions is established, and radial load distributed by the cosine function was applied, and combining the dynamic characteristics of the wheel, the fatigue analysis is performed by nCode DesignLife software to predict the fatigue life of wheel during the radial fatigue test. The results show that the middle part of the wheel spoke, the inner rim, the inner bead seat of the rim and the inner side of the rim are the main parts of the fatigue damage, which provides a basis for further optimization of the wheel structure.