In order to improve the rationality, timeliness, and balance of the workload of maintenance personnel, an equipment maintenance personnel deployment method based on immune algorithm is proposed. Analyze the maintenance personnel deployment during equipment overhaul; optimization method for equipment maintenance personnel is constructed by using matrix addressing and equalization evaluation and improving immune algorithm antibody generation methods and evaluation criteria. The results of the deployment is calculated by using Matlab programming and verified by Flexsim software simulation. The simulation results show that the method has better effect on the improvement of equipment maintenance efficiency and the balanced distribution of personnel workload.