In order to maximize the function of mechanical structure design, the design innovation of mechanical structure was studied. This paper analyzes the importance of innovative design to mechanical structure design, expounds the specific application of innovative design in mechanical structure design, and introduces the innovative design examples based on Teoriya Resheniya Izobreatatelskikh Zadatch (TRIZ). The results show that the use of innovative design can further improve the quality and performance of machinery, and promote the better development of machinery manufacturing industry.