In order to solve the problem of laser jamming to infrared imaging guidance missiles, a simulation system of the guidance missile was made. According to the principle of target imaging on infrared detector, the centroid tracking method was used to extract information and track the target. Target imaging model, guidance information extraction model, missile flight model, and laser jamming model were constructed respectively based on Simulink. By establishing the normal flight trajectory and the jamming trajectory after laser jamming, the factors affecting laser jamming are simulated and analyzed. The simulation result offers a reference for the protective engineering of important facilities.