To solve the question of big data analysis of submarine-launched weapons, research on operational application of submarine-launched weapons. Discuss the conception and characteristic of big data, emphasis on main idea and application area of neural network, swarm intelligence and correlation analysis. Operational application models of submarine-launched weapons techniques were proposed based on big data analysis techniques, including of weapon health evaluation, firepower distribution optimization, identifying of boundary condition. Feasibility analysis of big data analysis application in operational application of submarine-launched weapon was proposed. The result demonstrated that big data analysis techniques can be used to operational application and data processing. The study can provide a reference of solving operational application of submarine-launched weapons with big data analysis techniques.