As the computing error becomes bigger in slip regime while using the computational fluid dynamics method (CFD), and the direct simulation Monte Carlo method (DSMC) costs a lot of resources, velocity slip and temperature jump are considered to calculate the biconic flow by CFD method with slip condition. The Navier-Stokes (N-S) equations based on second-order slip conditions, simulate the biconic flow aerothermodynamics, the results were compared with the DSMC method and document data. Result shows that the slip condition makes the wall heat flux is nearer to DSMC simulation value, even in transition regime with low Knudsen number. Besides, the flow field structure which simulated by CFD with high Knudsen number and slip condition has error.