Aiming at the launching opportunity problem of ground to air missile and anti radiation missile confrontation, the launching opportunities are analyzed by simulation. Analyze the air-to-ground confrontation process, establish model of motion model. Based on this, calculate the launching time and simulate the attack and defense countermeasure process, the time cost and time differences between the two are analyzed respectively, put forward the best launching time. The research result is proved that this method is reasonable and feasible, which can be used as a reference for the operational use of weapon equipment.