Aiming at the explosive initiator life cycle safety control problem of certain type target-missile system, according to explosive initiator danger severity, carry out safety design in 3 levels, which including missile-equipment, target-missile and launching sate. Insensitive firing, power driver, constant overload armed and delay series connection armed were used to keep explosive initiator safety in the condition of electrostatic field, transportation, drop impact and abnormal impact. Isolation and working states are designed to ensure target-missile safety in un-launching process, such as transiting, storage, testing, simulation launch control docking test. The methods of stage-wise control, insurance series, single man-machine interface was used to ensure safety of target-missile system in the process of technical preparation, launch control docking and launching. Application results demonstrates that the safety methods are valid and reliable to the life cycle safety control of target-missile system.