For most of the existing infrared imaging adopting the correction method of one point＋two points, which increases structure complexity and overall power dissipation. Develop and design a new nonuniformity correction algorithm of infrared focal plane array. The paper introduces the three definition of nonuniformity and the common correction methods for nonuniformity correction. Based on test piece ULIS0304, describe non-uniformity correction of infrared focal plane array, then compare histograms before and after temperature correction. The results show that the nonuniformity of corrected image matrix is 0, and the algorithm is effective.