In order to improve the efficiency of automatic guided vehicle (AGV) motion control, this paper designs a three-dimensional model and motion model of AGV, and simulates and analyzes the motion model of AGV by Matlab/ Simulink. The PID control, fuzzy control, and fuzzy PID control are used to simulate the motion of AGV. The response time and control effect of the three control modes are obtained and analyzed from the walking distance and response time. The simulation results show that the established Simulink model is reliable and the fuzzy PID control effect is better than the fuzzy control and the general PID control, which provides a reference for AGV control research.