Based on the analysis of constraints of multi-target planning model and objective function, a multi-target integral planning model is established to meet the demand of multiple efficiency indexes optimization for anti-ship missile. According to the model, the minimum consumption of ammunition, the maximum destruction effect and the maximum average destruction effect of a missile is demonstrated through examples. The result shows that the model can represent multiple efficiency indexes and their mutual relationship, and can solve this kind of the firepower distribution problem effectively. The universality and flexibility is illustrated by considering all constraints of the model.