In order to improve the mobile efficiency of air defense missile weapon system, an efficacy evaluation method of air defense missile weapon system efficiency based on entropy-AHP and ADC is proposed. The theory of entropy-AHP and ADC is applied, and the basic procedures of the method are described. An example of two wheeled vehicles has been used to illustrate the rationality and feasibility of the method, solving the problems of index uncertainty information and subjective index weight. The method is an objective and precise method, and it provides a scientific decision foundation theoretically for design and develop to improve performance of the wheeled vehicle.