In order to reduce the mass of muzzle brake and improve firing accuracy and density, the application of titanium alloy in muzzle brake was researched. Based on the theory of computational fluid dynamics and the finite element theory and the application of computational fluid dynamics (CFD) numerical simulation and finite element analysis method, the entire process of the three-dimensional numerical simulation flow field of the muzzle brake and finite element analysis was accomplished. Stress distribution and deformation results of TC4 and gun-steel material of muzzle brake were obtained. The result shows that the using of TC4 can reduce the mass of muzzle brake in service conditions, then it can reduce design complexity of other components.