ICA algorithm will cause mix signal separation and extraneous solution in application, put forward an effective separated information maximization algorithm of sub-Gaussian distribution. Introduce basic principle of ICA and Infomax algorism, use Infomax algorism, separate voice signal from pronunciation signal. Make the modified model can be close to asymmetric distribution source signal, then verify it by simulation. The test results show that: the algorithm can be very close to asymmetric sub-Gaussian source signals, then it can acquire great separation quality and faster convergence speed.