In order to exert its effect farthest, introduces the principles and methods of Ergonomics into Non-lethal weapon design. Analyses the Ergonomics requirements of non-lethal weapon design, and aiming at the characteristics of human body physiological and psychological, summarizes idiographic requirements as follows: forfeiting resist ability, designing size and structure in reason, adopting middle psychogenic burthen, choosing appropriate derogation scheme, choosing “Green” raw and processed materials, setting anti-loot measures, etc. The study can provide reference for non-lethal weapon design.